E-080 Preclinical Evaluation of Mechanical Thrombectomy Devices in a Swine Clot Model

A novel method of thrombus preparation for use in a swine model for evaluation of thrombectomy devices.

We report the development of a novel technique of thrombus preparation for use in a swine model for evaluation of thrombectomy devices. The experimental thrombus prepared using plain sedimentation showed mechanical stability due to its solid fibrin-rich component. The thrombus also showed histologic similarity to the typical thromboemboli recovered from patients with stroke in the course of the...

In vivo evaluation of the Phenox CRC mechanical thrombectomy device in a swine model of acute vessel occlusion.

BACKGROUND AND PURPOSE Mechanical thrombectomy in ischemic stroke is of increasing interest as it is a promising strategy for fast and efficient recanalization. Several thrombectomy devices have been introduced to the armentarium of mechanical thrombectomy. Currently, new devices are under development and are continuously added to the neurointerventional tool box. Each device advocated so far h...

Preclinical investigations for thrombectomy devices--does it translate to humans?

A swine model to analyze arterial structural changes induced by mechanical thrombectomy.

We report a novel swine model that allows direct visualization of cervical arteries undergoing mechanical thrombectomy. The model also facilitates evaluation of histologic changes observed in the arteries after treatment. Swine superficial cervical arteries, which are similar in size and branching pattern to the human middle cerebral artery, were surgically exposed, occluded with experimental t...

Development of a preclinical model of ischemic cardiomyopathy in swine.

A number of promising therapies for ischemic cardiomyopathy are emerging, and the role of translational research in testing the efficacy and safety of these agents in relevant clinical models has become important. The goal of this study was to develop a chronic model of ischemic cardiomyopathy in a large animal model. In this study, 40 consecutive pigs were initially enrolled. To induce progres...